مقدمه کلی

مقالات تخصصی هپاتیت

چون هپاتیت یکی از دغدغه های مهم در حوزه بهداشت و درمان است. آزمایشگاه پاتوبیولوژی کوروش در جهت افزایش دانش در این حوزه با همکاری مرکز تحقیقات و گوارش و کبر دانشگاه علوم پزشکی بقیه الله و همچنین شبکه هپاتیت ایران مطالعات متعددی در زمینه انواع ویروس های هپاتیت انجام داده است.

عناوین مورد مطالعه به طور خلاصه عبارتند از:

بررسی ژنتیکی و ژنوتیپی ویروس های هپاتیت B و C

عوامل فارماکوژنتیکی

بررسی روند درمان بیماران مبتلا به هپاتیت های ویروسی

برخی از مقالات تخصصی هپاتیت که از دستاوردهای آزمایشگاه کوروش میباشد به شرح ذیل است:

• A Simple PCR-RFLP Method for Genotyping of IFNL4 rs368234815 Polymorphism in Patients With Chronic Hepatitis C
• The Role of Polymorphisms Near IFNL3 Gene as Predictors of Residual HCV RNA in Buffy Coat after Successful Antiviral Therapy

• The ITPA and C20orf194 Polymorphisms and Hematological Changes During Treatment With Pegylated-Interferon Plus Ribavirin in Patients With Chronic Hepatitis C

• Impact of IFNL4 rs12979860 and rs8099917 polymorphisms on response to Peg-Interferon- α and Ribavirin in patients with congenital bleeding disorder and chronic hepatitis C

• Prevalence of Hepatitis C Virus Core Amino Acid 70 Substitution and Genotypes of Polymorphisms Near the IFNL3 Gene in Iranian Patients With Chronic Hepatitis C

• The Role of Polymorphisms Near the IL28B Gene on Response to Peg-Interferon and Ribavirin in Thalassemic Patients With Hepatitis C

• The interferon lambda 4 rs368234815 predicts treatment response to pegylated‑interferon alpha and ribavirin in hemophilic patients with chronic hepatitis C

• Full Genome Ultra-Deep Pyrosequencing Identifies GG-TO-GA Hypermutation As Novel Predictor For Treatment Response To Pegylated Interferon Alfa-2A In Hbeag-Negativ Chronic Hepatitis B

• Significance Of Micro RNA-122 In Patients with Chronic Hepatitis C On Interferon Therapy

• The Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study

• The rs12979860 and ss469415590 polymorphisms of IFNL4 gene are in strong linkage disequilibrium in Caucasian patients with chronic hepatitis C

• Study of HBsAg escape mutations in chronic hepatitis B patients under treatment with nucleos (t) ide analogues

• Distribution of IL28B Genotypes in Iranian Patients with Chronic Hepatitis C and Healthy Individuals

• Treatment of Chronic Hepatitis C Infection: Update of the Recommendations from Scientific Leader’s Meeting-28th July 2011-Tehran, IR Iran

• Development and Validation of a Simple, Rapid and Inexpensive PCRRFLP Method for Genotyping of Common IL28B Polymorphisms: A Useful Pharmacogenetic Tool for Prediction of Hepatitis C Treatment Response

• Detection of the YMDD Motif Mutations Rate in Chronic Hepatitis B Patients Treated with Lamivudine

• A facile PCR-RFLP method for genotyping of ITPA rs1127354 and rs7270101 polymorphisms